You may get this error, if the WinSCP .NET assembly package was downloaded using Microsoft Internet Explorer or Edge browsers and extracted using Windows File Explorer. These applications, under certain circumstances, block libraries downloaded from Internet as potentially harmful, what prevents their loading.
To remove the block, open Properties for the
WinSCPnet.dll in Windows File Explorer. On an initial General page, click Unblock button on Security section. You may need to restart your IDE (if any), for the change to apply.