That make sense. Sorry as I am new to .NET WinSCP Assembly and SSH/SFTP/FTP. Thank you.

What does this question have to do with WinSCP?
Anyway, indeed, SFTP and FTPS are two completely unrelated protocols. So there's no reason to expect that an SFTP server supports FTPS protocol (and vice versa).

I am creating an automation script for our partners in the Healthcare using SFTP Protocol. I am using Porta SFTP Server (https://portasftpserver.com/portable-sftp-server-community-edition/) for the testing, and I have observed that I cannot test FTP/S Protocol with port 21 with this software. Does anyone encounter the same?