Sorry, I think what I meant was a "Session Location Profile". This would be similar to how most FTP clients can automatically select a local and remote directory of your choice after logging in.
https://winscp.net/eng/docs/faq_dir_default
[quote]Hmm... OK, interesting. I was kind of hoping there might be a way to do this without having to create separate shortcuts for each profile I have.[/qoute]
You can omit the session on command-line. You'll get login dialog on startup, where you can select the session to perform synchronization on.