No. Actually, from my experience, people are moving from FileZilla to WinSCP exactly for this reason. They do not like that confirmation in FileZilla. When you are editing a file, it's only natural that you want the file to be overwritten. When you are editing a local file, a file editor does not ask you either, if you are really sure you want to overwrite a file, when you are saving it.

I am moving from filezilla to winSCP as filezilla has 0 confirmation for dragging and dropping folders into each other (after 16 YEARS)

i've gotten winscp setup pretty decently but something that really bugs me is when I open a text file from remote directory, edit it and save it there is no confirmation prompt for uploading it again, it just does it automatically. On filezilla a window appears saying "A file previously opened has been changed, upload this file back to the server? YES/NO" Is there a way to add such prompt to winSCP? Thanks.