Pros and cons of Winscp with S3

It seems there are two options to use Winscp with Amazon S3. Option 1 is to use native S3 REST API by selecting Amazon S3 as node type in WinSCP, option 2 is to use Amazon Transfer Family with FTPS and use WinSCP as usual, as a FTPS client.
Which one is best, especially for performance. I plan to use S3 to do daily backups where I will need to synchronize thousands of files for a total of approximatively 500 Go.

I do not think this is a question we can answer here in full.

But definitely, use SFTP, not FTPS.