Changing remote VMS directory issue/transferring file from local win11 computer to remote VMS issue

I started to use WinSCP to transfer files between my windows computer and remote. I encountered two issues:
1. on the panel for remote VMS system, changing directories worked for some directories, but failed for some other directories.
2. I can transfer file from remote VMS system to local PC, but failed to transfer file from local PC to remote VMS system.

Please refer to the attached document for error messages. I played with WinSCP settings for hours, but no luck so far. Any help would be appreciated.

Thanks,
Nan